Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2011-03-22
2011-03-22
Brusca, John S (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C435S004000, C707S793000, C703S011000
Reexamination Certificate
active
07912651
ABSTRACT:
A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.
REFERENCES:
patent: 4568649 (1986-02-01), Bertoglio-Matte
patent: 5569588 (1996-10-01), Ashby et al.
patent: 5631153 (1997-05-01), Capecchi et al.
patent: 5777888 (1998-07-01), Rine et al.
patent: 5994076 (1999-11-01), Chenchik et al.
patent: 6004755 (1999-12-01), Wang
patent: 6013437 (2000-01-01), Luria et al.
patent: 6146830 (2000-11-01), Friend et al.
patent: 6656695 (2003-12-01), Berg et al.
patent: WO 95/06132 (1995-03-01), None
patent: WO 96/23075 (1996-08-01), None
patent: 01/51664 (2001-07-01), None
patent: 02/44732 (2002-06-01), None
Shinkai et al. A Novel Human CC Chemokine, Eotaxin-3, Which is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils. J. of Immunology vol. 163, pp. 1602-1610 (1999).
Konstantopoulos et al. Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow. J. of Leukocyte Biology vol. 61, pp. 179-187 (1997).
Rice et al. Development ofa High Volume Screen to Identify Inhibitors of Endothelial Cell Activation. Anal. Biochemistry. vol. 241, pp. 254-259 (1996).
Monks et al. The NOC anti-cancer drug screen:a smart screen to identify effectors of novel targets. Anti-Cancer Drug Design vol. 12, pp. 533-541 (1997).
Altschuel et al., Issues in Searching Molecular Sequence Databases, Nature Genetics, (1994), 6: 119-129.
Blackstock et al., Proteomics: Quantitive and Physical Mapping of Cellular Proteins, Tibtech, (1999), 17: 121-127.
Hatzimanikatis et al., Proteomics: Theoretial and Experimental Considerations, Biotechnol., (1999), 15: 312-318.
Heller et al., Discovery and Analysis of Inflammatory Disease-Related Genes Using CDNA Microarrays, Proc. Natl. Acad. Sci., (1997), 94: 2150-2155.
Mullner et al., Proteomincs: A New Way for Drug Target Discovery, Arzneim-Forsch., (1998), 48(1): 93-95.
Nellen et al., What Makes an MRNA Anti-Sense-Itive?, TIBS, (1993), 18: 419-423.
May et al., Effects of Protein Tyrosine Kinase Inhibitors on Cytokine-Induced Adhesion Molecule Expression by Human Umbilical Vein Endothelial Cells, Brit. Journal, of Pharmacology, 1996, 118(7): 1761-1771.
Rice et al., Development of a Heigh Volume Screen to Identify Inhibitors of Endothelial Cell Activation, Analytical Biochem., 1996, 241(2): 254-259.
Hausner et al., The Comparative Growth Assay: Examining the Interplay of Anti-Cancer Agents With Cells Carrying Single Gene Alterations, Neoplasia, Doyma, 1999, 1(4): 356-367.
Bhalla et al., “Emergent properties of networks of biological signaling pathways,” Science, 1999, 283(5400):381-387.
Hughes et al., “Functional discovery via a compendium of expression profiles,” Cell, 2000, 102(1):109-126.
Lavé et al., “The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans,” Pharm. Res., 1997, 14(2):152-155.
Schmidt-Weber, Carsten B; et al., “DNA Arrays in Allergy and Immunology”, Int Arch Allergy Immunology, Sep. 1, 2001, 126(1):1-10.
Berg Ellen L.
Butcher Eugene C.
Melrose Jennifer
Plavec Ivan
BioSeek LLC
Bozicevic Field & Francis LLP
Brusca John S
Sherwood Pamela J.
LandOfFree
Function homology screening does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Function homology screening, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Function homology screening will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2649023