Fumagillol derivatives and processes for preparing the same

Details Fumagillol derivatives and processes for preparing the same Fumagillol derivatives and processes for preparing the same

1999-05-13

2000-05-16

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549332, 549539, 549554, 549561, A61K 31335, C07D30308, C07D30312

Patent

active

060638125

ABSTRACT:
Compounds useful as angiogenesis inhibiting agents and processes for their preparation are disclosed. In one embodiment, the compounds of the invention are represented by Formula 1: ##STR1## Also disclosed is a pharmaceutical composition for inhibiting angiogenesis in a mammal, said composition comprising a compound of Formula 1, or a pharmaceutically acceptable salt thereof, as an active ingredient.

REFERENCES:
Tarbell, D. S., et al., "The Chemistry of Fumagillin," J. Amer. Chem. Soc., 83:3096-3113 (1961).
Marui,S. and Kishimoto,S., "Chemical Modification of Fumagillin. II. 6-Amino-6-deoxyfumagillol and Its Derivatives," Chem. Pharm. Bull., 40:575-579 (1992).
Marui et al., "Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols," Chem. Pharm. Bull., 40:96-101 (1992).
Billington, David C., "Angiogenesis and Its Inhibition: Potential New Therapies In Oncology and Non-Neoplastic Diseases," Drug Design and Discovery, 8:3-35 (1991).

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