Fumagillol derivatives and preparing method thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S435000, C549S551000, C544S238000, C544S298000, C546S281700

Reexamination Certificate

active

07087768

ABSTRACT:
The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angeogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc., and diabetic retinopathy related to angeogeneois, and also a method for preparing the same.

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Kruger, EA et al, TNP-470: an angiogenesis inhibitor in clinical development for cancer, Exp. Opin. Invest. Drugs (2000) 9(6), 1383-1396.

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