Fullerene compositions for magnetic resonance spectroscopy and i

Details Fullerene compositions for magnetic resonance spectroscopy and i Fullerene compositions for magnetic resonance spectroscopy and i

1991-08-19

1993-09-28

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

534 15, 423263, 423445, 436173, 1286534, 570130, G01N 2408, C07C 1908, C01F 1700, C01B 3102

Patent

active

052484980

ABSTRACT:
Methods and compositions are disclosed for enhancing magnetic resonance imaging and spectroscopy which utilize derivatives of the even-numbered carbon clusters, known as "fullerenes." Perfluorinated carbon clusters of the formula C.sub.n F.sub.m, wherein n is in the range from 30-100 and m.ltoreq.n, may be used for fluorine-19 imaging. Incorporating paramagnetic metal species into the carbon cluster cage improves fluorine and proton imaging.

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patent: 5132105 (1992-07-01), Remo
Kroto, H. W. et al. Nature 318: 162-3 (1985).
F. Diederich, "From Soot to Superconductors", Angew. Chem. Int. Ed. Engl., vol. 30, No. 6, pp. 678-680 (1991).
H. Selig, et al., "Fluorinated Fullerenes", J. Am. Chem. Soc., vol. 113, pp. 5475-5476 (1991).
Alan L. Mackay, "Carbon Crystals Wrapped Up", Nature, vol. 347, pp. 336-337 (1990).
Harold Kroto, "Space, Stars, C.sub.60 and Soot", Science, vol. 242, pp. 1139-1145 (1988).
W. Kratschmer et al., "Solid C.sub.60 : a new form of carbon", Nature, vol. 347, pp. 336-337 (1990).
Rudy M. Baum, "Simple Synthesis of C.sub.60 Molecule Triggers Intense Research Effort", Chemical and Engineering News, pp. 22-25 (Oct. 29, 1990).

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