Full length polynucleotide coding chicken type II collagen...

Details Full length polynucleotide coding chicken type II collagen... Full length polynucleotide coding chicken type II collagen...

2011-07-05

2011-07-05

Long, Scott (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S069100, C435S349000, C435S320100, C530S356000, C536S023500

Reexamination Certificate

active

07973010

ABSTRACT:
The present invention relates to a nucleic acid molecule as set forth in SEQ ID NO:1 comprising a polynucleotide sequence encoding full length chicken type II collagen (CCII), or a fragment thereof in possession of the same biological functions as well as CCII encoded thereof. It also relates to a method for producing CCII, and its use in the manufacture of a medicament for treating and/or preventing rheumatoid arthritis (RA). The invention specifically relates to a pharmaceutical composition for treating and/or preventing osteoarthritis and RA, to a food or beverage composition, and to a food additive composition, containing CCII prepared according to the method described in this invention, and the use of the nucleic acid molecules of the present application in gene therapy.

REFERENCES:
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patent: 02/058484 (2002-08-01), None
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Chicken Collagen II amino acid sequence. accession No. AAK98621.
Protein alignment—chicken COL2A1 and SEQ1-translations.
DNA alignment—chicken COL2A1 cDNA and SEQ1.
DNA alignment—chicken COL2A1 cDNA and SEQ2.
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Chicken collagen, type 2A1, complete coding sequence.
MEMO—sequence interpretation.
GenBank—chicken collagen 2a—mRNA references (2011).
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Hyun-Duck Nah, et al., “Type II Collagen mRNA Containing an Alternatively Spliced Exon Predominates in the Chick Limb Prior to Chondrogenesis”, The Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, vol. 266, No. 34, XP002529705, May 15, 1991, pp. 23446-23452.
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David E. Trentham, et al., “Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis”, Science, vol. 261, No. 5129, XP002529769, Sep. 24, 1993, pp. 1727-1730.

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