Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-08-30
2011-08-30
Olson, Eric S (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S053000, C514S061000, C536S055100, C536S055200, C536S123000, C536S123100, C536S123130
Reexamination Certificate
active
08008275
ABSTRACT:
A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate selective proliferation of mammalian natural killer (NK) cells and γδT cells. These compounds are useful as pharmaceuticals, particularly as immunostimulants, e.g., in the treatment of cancer and viral infections.
REFERENCES:
Lee et al., “Characterization of oligosaccharide moieties of glycopeptides by microwave-assisted partial acid hydrolysis and mass spectrometry” Rapid Communications in Mass Spectrometry (2005) vol. 19 pp. 1545-1550.
Misevic et a;., “Carbohydrate-Carbohydrate Interactions of a Novel Acidic Glycan Can Mediate Sponge Cell Adhesion” The Journal of Biological Chemistry (1993) vol. 268 No. 7 pp. 4922-4929.
Hashii et al., “Specific detection of Lewis x-carbohydrates in biological samples using liquid chromatography/multiple-stage tandem mass spectrometry” Rapid Communications in Mass Spectrometry (2005) vol. 19 pp. 3315-3321.
Roon et al., “Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides” Biological and Medicinal Chemistry (2005) vol. 13 pp. 3553-3564.
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