FSH-releasing peptides

Details FSH-releasing peptides FSH-releasing peptides

1987-08-31

1990-11-27

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 514800, 530313, 530399, A61K 3724, C07K 710, C07K 720

Patent

active

049735772

ABSTRACT:
A 28,000-dalton protein with FSH-releasing activity is isolated from porcine follicular fluid in a multi-step procedure including gel filtration, ion exchange chromatography and several reverse-phase high-performance liquid chromatography steps. The 28 kD protein promotes secretion of FSH, but not of LH, in a rat anterior pituitary monolayer culture system, exhibiting an EC.sub.50 of 0.5 ng/ml. These peptides are dimers of inhibin .beta.-chains of mammals, and homodimers or heterodimers of the .beta..sub.A and .beta..sub.B chains are biologically active to regulate fertility of various mammalian species, including humans.

REFERENCES:
patent: 4409139 (1983-10-01), Ling et al.
patent: 4734398 (1988-03-01), diZerega
patent: 4764502 (1988-08-01), diZerega
patent: 4798885 (1989-01-01), Mason
Goodman and Gilman, The Pharmaceutical Basis of Therapeutics, 3rd. ed., The MacMillan Co., N.Y., 1965, pp. 1527-1531.
Proc. Nat'l. Acad. Sci., 82, pp. 7217-7221, (1985).
Biochem. and Biophys. Res. Commun., 133, (1985), 120-127.
Brain, Res. Bull., vol. 10, (1983), 623-629.

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