FSH

Details FSH FSH

1985-01-30

1990-05-08

Huleatt, Jayme A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435320, 4352102, 4351723, 935 13, 935 32, C12P 2100, C12P 2102, C12N 1500, C12N 500

Patent

active

049238051

ABSTRACT:
Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.

REFERENCES:
patent: 4383034 (1983-05-01), Sugimoto
patent: 4419446 (1983-12-01), Howley et al.
patent: 4468464 (1984-08-01), Cohen et al.
Pierce et al., 1981, "Glycoprotein Hormones: Structure and Function" Ann. Rev. Biochem v 50, pp. 465-496.
Fiddes et al., 1980, "The CDNA for the .beta.-Subunit of Human Chorionic Gonodotropin Suggests Evolution of a Gene . . . " Nature v 286, pp. 684-687.
Chappel, Scott, et al., Endocrine Reviews, vol. 4, No. 2, pp. 179-211, 1983.
Fiddes et al., 1981, "The Gene Encoding the Common Alpha Subunit of the Four Human Glycoprotein Hormones" J. Mol. Appl. Gen. v 1, pp. 3-18.
Elder, J. T. et al., Ann Rev. Genet, vol. 15, pp. 328-330, 1981.
Rice, D. et al., Proc. Natl. Acad. Sci., vol. 79, pp. 7862-7865, 1982.
Moriarty, A. et al., Proc. Natl. Acad. Sci., vol. 78, pp. 2606-2610, 1981.
Lustbader, J. et al., 68th Annual Meeting of the Endocrine Society, Program and Abstract, Abstract No. 513, Jun, 1986.

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