Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-10-24
1997-04-15
Wilson, James O.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 25, 514 58, 514917, 514922, 514974, 536 41, 536 182, 536103, 536119, A61K 3172, C07H 1506
Patent
active
056209614
ABSTRACT:
A specialized derivative of fructose in which the compound is a fructose ester complexed with .beta.-cyclodextrin. Preferably, the fructose derivative is fructosehexanoate .beta.-cyclodextrin complex, and more preferably the fructose derivative is fructose-1-O-hexanoate .beta.-cyclodextrin complex. Fructose pentanoate and fructose heptanoate .beta.-cyclodextrin complexes are also included within the scope of the invention, and the fructose ester and the .beta.-cyclodextrin must be combined in approximately molar equivalent amounts. The present invention also includes a method for treating animals and humans with the instant fructose derivatives, to protect against tissue damage caused by doxorubicin cytotoxicity (particularly doxorubicin-induced cardiomyopathy or mucositis), ischemia, radiation damage and other sources of free oxygen radical cellular damage to the tissue of living animals and humans. The present fructose derivative is an active agent which is appropriately incorporated in a pharmaceutical dosage form which may be but need not be an aqueous solution, and the pharmaceutical composition may be given in a wide range of doses to address either acute or chronic needs.
REFERENCES:
patent: 4546095 (1985-10-01), Markov
patent: 5124318 (1992-06-01), Gatti et al.
Markovic Nenad S.
Markovic Olivera T.
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