Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1996-01-16
2000-04-25
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
4353201, 435325, 435410, 435243, 536 234, 536 241, C12P 2100, C12N 1563, C12N 1585, C07H 2104
Patent
active
060542985
ABSTRACT:
Isolated DNA encoding a protein or polypeptide having at least one biological activity of a vertebrate fringe protein, as well as the protein or polypeptide encoded thereby, are described. Assays for identifying agents which alter the expression of the described fringe genes and assays for agents which alter the production of angiogenic precursors, the formation of the apical ectodermal ridge and the subdivisions of the neural tube are also described.
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C. Rodriguez-Esteban et al., "Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb", Nature 386 (27):360-366 (1997).
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Irvine, K.D. and Wieschaus, E., "fringe, a Boundary-Specific Signaling Molecule, Mediates Interactions between Dorsal and Ventral Cells during Drosophila Wing Development", Cell 79 :595-606 (1994).
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Laufer Edward M.
Orozco Olivia E.
Tabin Clifford J.
Beckerleg Anne Marie S.
President and Fellows of Harvard College
Stanton Brian R.
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