Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2011-08-23
2011-08-23
Minnifield, Nita M (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C530S324000, C530S325000, C530S326000, C435S007100, C435S252700, C435S023000, C435S069100, C436S546000
Reexamination Certificate
active
08003753
ABSTRACT:
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.
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Aoki Kei Roger
Fernandez-Salas Ester
Steward Lance E.
Allergan Inc.
Kenton Abel Debra Condino
Minnifield Nita M
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