Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-05-05
2008-08-19
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07413862
ABSTRACT:
This invention relates to the field of detecting interacting molecules. The invention provides a set of a first and a second probe, each such probe provided with a dye allowing energy transfer; at least one probe provided with a reactive group allowing juxtaposing the first and second probe. A method is provided for detecting at least two interacting molecules at the single cell level using of a set of probes according to the invention.
REFERENCES:
patent: 6235535 (2001-05-01), Keinanen et al.
patent: 7081336 (2006-07-01), Bao et al.
patent: 2002/0081617 (2002-06-01), Burnanda et al.
patent: 2003/0059811 (2003-03-01), Djaballah et al.
patent: 2003/0228603 (2003-12-01), Cload et al.
patent: 2004/0110245 (2004-06-01), Nagamune et al.
patent: 1 382 965 (2004-01-01), None
patent: WO 99/18124 (1999-04-01), None
patent: WO 01/33199 (2001-05-01), None
patent: WO 2004/042404 (2004-05-01), None
PCT International Search Report, PCT/NL03/00777, dated Mar. 5, 2004.
PCT International Preliminary Examination Report, PCT/NL03/00777, dated Jan. 13, 2005.
Lundin et al., “Development of a Time-Resolved Fluorescence Resonance Energy Transfer Assay (Cell TR-FRET) for Protein Detection on Intact Cells,” Analytical Biochemistry, 2001, pp. 92-97, vol. 299.
Bader et al., “A cGMP-Dependent Protein Kinase Assay for High Throughput Screening Based pf Time-Resolved Fluorescence Resonance Energy Transfer,” Journal of Biomolecular Screening, 2001, pp. 255-263, vol. 6, No. 4.
Szollosi et al., “Application of Fluorescence Resonance Energy Transfer in the Clinical Laboratory: Routine and Research,” Cytometry (Communications in Clinical Cytometry), 1998, pp. 159-179, vol. 34.
Kane et al., Development of a Binding Assay for p53/HDM2 by Using Homogenous Time-Resolved Fluorescence, Analytical Biochemistry, 2000, pp. 29-38, vol. 278.
Staal Frank Jakob Theodor
van Dongen Jacobus Johannes Maria
Erasmus Universteit Rotterdam
TraskBritt
Whisenant Ethan
LandOfFree
FRET probes and methods for detecting interacting molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with FRET probes and methods for detecting interacting molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and FRET probes and methods for detecting interacting molecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4004693