Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation
Patent
1988-07-27
1989-06-20
Evans, F. L.
Optics: measuring and testing
By dispersed light spectroscopy
With sample excitation
2504581, G01N 2164
Patent
active
048404853
ABSTRACT:
Frequency domain cross-correlation fluorometers may be improved over present designs by providing a coherent signal at one frequency to means for detecting luminescence from a sample, which is elicited by light modulated at another frequency, in which the two frequencies, obtained from a pair of phase-locked loop frequency synthesizers, are different from each other by at least 100 hertz, which is a significantly greater difference than used in corresponding prior art fluorometers. This permits the use of the phase-locked loop frequency synthesizers, rather than the currently used direct synthesis synthesizers, providing significant advantages.
REFERENCES:
patent: 3886370 (1975-05-01), Schubert et al.
patent: 4594511 (1986-06-01), Cooper et al.
"MOS Replaces Crystal IC as Synthesizer," Electrotechnolgoy, vol. 5, No. 3, p. 73, Jul. 1977.
Giles, T. G., "Versatile LSI Frequency Synthesizer System", Electronic Components and Applications, vol. 2, No. 2, Feb. 1980, pp. 91-94.
Marconi Instruments 10 kHz to 1000 MHz AM/FM Signal Generator 2022--Issue 1 8/84 (Brochure).
Syntest Corporation Data Sheet SM-105 Brochure.
Industria Strumentazioni Scientifiche--I.S.S. Greg 200 Multifrequency Cross-Correlation Phase and Modulation Fluorometer (Brochure).
Chemical Physics Letters--vol. 119, No. 2,3 (pp. 217-222) Aug. 30, 1985.
The Journal of Biological Chemistry--1984 by The American Society of Biological Chemists, Inc. entitled: Detection of Phospholipid Phase Separation, vol. 259, No. 22 Issue of Nov. 25, pp. 14011-14017, 1984.
E. Gratton & B. Barbieri entitled: Multifrequency Phase Fluorometry Using Pulsed Sources: Theory and Applications--28 Spectroscopy, vol. 1, No. 6 --pp. 28-38.
Enrico Gratton et al. entitled: Multifrequency Phase and Modulation Fluorometry--Ann. Rev. Biophys. Bioeng. 1984, 13:105-124.
David M. Jameson et al.--entitled: The Measurement and Analysis of Heterogeneous Emissions by Multifrequency Phase and Modulation Fluorometry--Applied Spectroscopy Reviews, 20(1), 55-106 (1984).
E. Gratton et al., entitled: A Continuously Variable Frequency Cross-Correlation Phase Fluorometer with Picosecond Resolution, Biophysical Society , vol. 44, Dec. 1983, pp. 315-324.
Tiziana Parasassi et al., entitled: Study of Heterogeneous Emission of Parinaric Acid Isomers Using Multifrequency Phase Fluorometry--1984 American Chemical Society, pp. 5660-5664.
Tiziana Parasassi et al., entitled: Time-Resolved Fluorescence Emission Spectra of Laurdan in Phospholipid Vesicles by Multi-Frequency Phase and Modulation Fluorometry--Cellular and Molecular Biology 32(1), 103-108, 1986.
Enrico Gratton et al., entitled: New Approach to Phase and Modulation Resolved Spectra--1985 American Chemical Society--Analytical Chemistry, vol. 57, No. 8, Jul. 1985, pp. 8-11.
E. Gratton et al., entitled: Multifrequency Cross-Correlation Phase Fluorometer Using Synchrotron Radiation--American Institute of Physics Rev. Sci. Instrum., vol. 55, No. 4, Apr. 1984, pp. 486-494.
J. Ricardo Alcala et al., entitled: A Multifrequency Phase Fluorometer Using the Harmonic Content of a Mode-Locked Laser--Analytical Instrumentation, 14(3&4), 225-250 (1985).
Ellis Garrettson
Evans F. L.
I.S.S. (U.S.A.) Inc.
LandOfFree
Frequency domain cross-correlation fluorometry with phase-locked does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Frequency domain cross-correlation fluorometry with phase-locked, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Frequency domain cross-correlation fluorometry with phase-locked will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-522637