Freeze-drying process for the preparation of meningococcus vacci

Details Freeze-drying process for the preparation of meningococcus vacci Freeze-drying process for the preparation of meningococcus vacci

1977-08-05

1979-01-16

Sebastian, Leland A.

Drying and gas or vapor contact with solids

Apparatus

With means to treat gas or vapor

34 13, 34 15, 34 20, 424 88, 424 92, F26B 506

Patent

active

041342143

ABSTRACT:
The purified Group A polysaccharide antigen isolated from N. meningitidis for vaccination against this type of bacterial meningitidis is prepared from an isotonic ratio of aqueous sodium chloride solution freeze-dried at temperatures of from -20.degree. C. to -30.degree. C. This low temperature lyophilization dries the sodium chloride polysaccharide menstrum without loss of molecular weight, i.e., potency.

REFERENCES:
patent: 3449885 (1969-06-01), Starkey
patent: 3594913 (1971-07-01), Tooby
patent: 3607858 (1971-09-01), Querry
Benedict et al., Appl. Microbiol, vol. 6, 1958, pp. 401-407.

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