Freeze-dried preparation containing monoclonal antibody

Details Freeze-dried preparation containing monoclonal antibody Freeze-dried preparation containing monoclonal antibody

1994-11-14

1999-06-01

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4241421, 5303881, 53038815, C07K 1600, A61K 39395

Patent

active

059088265

ABSTRACT:
A freeze-dried monoclonal antibody preparation is prepared by adding to a solution of the monoclonal antibody gelatin or carboxylic acid or its salt, to prevent denaturation of the monoclonal antibodies during freeze-drying. Freeze-dried monoclonal antibody preparations having stablized antigen-binding activity result and may be used as an adminiculum for immunoauxotherapy for prophylaxis and treatment of bacterial infectious diseases and viral infectious diseases.

REFERENCES:
Azrin M.A., American Heart Journal, vol. 124(3), pp. 753-768 (1992)); specifically in the section "Summary," left column on page 766.
Katus. et al., Circulation Abstracts, vol. 68(4), p. III-80 (1983).
O'oka, H. et al., Microbial. Immunol., vol. 36(12), pp. 1305-1316 (1992) specifically in line 11-19, pp. 1314, line 4-1 from the bottom of the same page, and line 3-7, pp. 1315.
Chemical Abstract 101. 53015.mu. (1984)--Chemical Abstract of SU 700132.
Vox Sang. 51:81-86 (1986) Tomeno et al. "A New Intact Immunoglobulin for Intravenous Use Stabilized by Chemically Modified Gelatin Derivatives" pp. 81-86.
Borrebaeck, Journal of Immunological Methods, vol. 123 pp. 157-165 (1989).
Waldmann, Science, vol. 252, pp. 1657-1662 (1991).
Spalding, Bio/Technology, vol. 11, pp. 428-429 (1993).

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