Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-06-10
1989-12-26
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514769, 514784, 514970, A61K 3147, A61K 4700
Patent
active
048898627
ABSTRACT:
Freeze-dried pharamceutical compositions of antitumor phenylquinoline carboxylic acids, such as 6-fluoro-2-(2'-fluoro-1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, sodium salt, reconstitutable to stable, aqueous, injectable compositions are provided. These compositions use a stabilization system consisting essentially of bile salt, such as sodium cholate or sodium desoxycholate, and a base or buffer that will provide a pH of about 8.5-11 upon a aqueous reconstitution. Glycine is the preferred buffer.
REFERENCES:
patent: 4036954 (1977-07-01), Murakami et al.
patent: 4680299 (1987-07-01), Hesson
Remington's Pharmaceutical Sciences, 15th Ed. Maek Pub., pp. 1466 & 1483-1485.
"The Characterization of Sodium Cholate Solubilized Rhodopsin", R. A. Henselman & M. A. Cusanovich, Biochemistry, vol. 13, No. 25, 1974, pp. 5199-5203.
E. I. Du Pont de Nemours and Company
Henley III Raymond J.
Robinson Douglas W.
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