Freeze-dried dosage forms and methods for preparing the same

Details Freeze-dried dosage forms and methods for preparing the same Freeze-dried dosage forms and methods for preparing the same

1989-12-28

1993-02-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424 7808, 424 7824, 424 7831, 424 7837, 424439, 424440, 424441, 424484, 424486, 426 1, 426 2, 5147721, 5147722, 5147723, 5147724, 514777, 514778, 514779, 514780, 514781, 514782, A61K 3174, A61K 968, A61K 914, A01N 2508

Patent

active

051888254

ABSTRACT:
A method of preparing a freeze-dried dosage form including a water soluble active agent is disclosed. The water soluble active agent is bonded to an ion exchange resin to form a substantially water insoluble complex. This complex is then mixed with a compatible carrier and freeze-dried. The resulting freeze-dried dosage form contains an effective unit dosage amount of the active agent and exhibits enhanced compositional and physical stability, as well as permitting processing according to conventional freeze-drying techniques.

REFERENCES:
patent: 4427793 (1984-01-01), Reed et al.
patent: 4882151 (1989-11-01), Yang et al.

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