Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2009-10-20
2011-10-25
Lucas, Zachariah (Department: 1648)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C424S211100, C424S209100, C424S204100
Reexamination Certificate
active
08043610
ABSTRACT:
The objects of the present invention are to provide a freeze-dried composition of an inactivated virus envelop having membrane fusion activity which can be stored at higher temperatures without losing the ability to introduce foreign matters and to provide a method of introducing a foreign matter into a cell with high efficiency.The present invention provides a freeze-dried composition for introducing a foreign matter which comprises an inactivated virus envelope having membrane fusion activity, and at least one stabilizer selected from the group consisting of a protein hydrolysate, leucine, an L-arginine-acid and a polysaccharide, and a method of introducing a foreign matter using the freeze-dried composition containing an inactivated virus envelope.
REFERENCES:
patent: 5631237 (1997-05-01), Dzau et al.
patent: 6913923 (2005-07-01), Kaneda
patent: 7504098 (2009-03-01), Kaneda et al.
patent: 2003/0202988 (2003-10-01), Chaplin et al.
patent: 2004/0253272 (2004-12-01), Kaneda
patent: 299 213 (1992-04-01), None
patent: 0 872 249 (1998-10-01), None
patent: 1 170 363 (2002-01-01), None
patent: 1 420 065 (2004-05-01), None
patent: 57-95917 (1982-06-01), None
patent: 2000/502672 (2000-03-01), None
patent: 00/29024 (2000-05-01), None
patent: 00/34444 (2000-06-01), None
patent: 01/57204 (2001-08-01), None
patent: 03/014338 (2003-02-01), None
Caldwell and Lyles. Interaction of Sendai Virus Proteins with the Cytoplasmic Surface of Erythroctye Membranes following Viral Envelope Fusion. J of Biological Chemistry. 1981. 256(10): 4838-4842.
Dzau, V.J. et al., “Fusigenic Viral Liposome for Gene Therapy in Cardiovascular Diseases” Proc. Natl. Acad. Sci. USA, vol. 93, pp. 11421-11425, Oct. 1996.
Kaneda, Y. et al., “Gene Therapy Using HVJ-Liposomes: The Best of Both Worlds?”; Molecular Medicine Today, vol. 5, p. 298-303, Jul. 1999.
Horning Michelle S
Ishihara Sangyo Kaisha Ltd.
Lucas Zachariah
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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