Freeze-dried composition containing a 2-dimethylamino etoposide

Details Freeze-dried composition containing a 2-dimethylamino etoposide Freeze-dried composition containing a 2-dimethylamino etoposide

1992-05-20

1994-07-05

Collins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 35, 536 172, 536 181, A61K 3170

Patent

active

053267532

ABSTRACT:
The present invention relates to a freeze-dried preparation comprising (1) about 5 to about 50 W/W% of a non-volatile acid and/or a salt thereof, (2) about 10 to about 95 W/W% of 4-O-(2-deoxy-2-dimethylamino-4,6-O-ethylidene-.beta.-D-glucopyranosyl)-4'- demethyl-4-epipodophyllotoxin hydrochloride and (3) 0 to about 85 W/W% of at least one sugar as a stabilizer.

REFERENCES:
patent: 4713246 (1987-12-01), Begum et al.
patent: 4716221 (1987-12-01), Umezawa et al.
patent: 4757138 (1988-07-01), Fujii et al.
patent: 4772589 (1988-09-01), Kaplan et al.
patent: 4853467 (1989-08-01), Vyas et al.
patent: 4927638 (1990-05-01), Bykadi et al.
patent: 4935504 (1990-06-01), Saulnier et al.
patent: 4997923 (1991-03-01), Izawa et al.
Osol ed., Remington's Pharmaceutical Sciences, 16th Ed., Mack Publishing Co., Easton, Pa. 1980, pp. 1483-1484.
Ludwig et al; "Chemical and Biological Stability of Anticancer Drugs Used in a Human Tumor Clonogenic Assay," Cancer Chemother. Pharmacol. 12:142-145 (1984); Chem. Abstr., 101, p. 345, Abstr. No. 116635u (1984).
Sato et al., "Antitumor Etoposide Injection" (Jp SN 60,239,415); Chem. Abstr., 104, p. 449, Abstr. No. 95509a (1986); only Abstract provided.
Hamon et al., "Study on the Stability in Dilute Solutions Destined for Perfusion of Two Antimitotics Derived from Podophyllotoxin: Etoposide (VP16) and Teniposide (VN26)," S.T.P. Pharma., 3(1), 33-40 (1987); Chem. Abstr., 107, p. 378, Abstr. No. 83767g (1987); only Abstract provided.
Tanaka et al., "Stability of Etoposide," Kagaku Ryoho no Ryoiki, 3(9), 1459-1467 (1987); Chem. Abstr., 107, p. 357, Abstr. No. 223147g (1987); only Abstract provided.
Grant et al. eds., Grant & Hackh's Chemical Dictionary, McGraw-Hill Book Company, New York, 1987, p. 346.
Seargeant et al., "In Vitro Stability and Compatibility of Daunorubicin, Cytarabine and Etoposide," Cancer Treatment Repts., 71(12):1189-1192; Chem. Abstr., 108, p. 327, Abstr. No. 26897w (1988).
Shah et al; "Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of Etoposide," Pharmaceutical Res., 6(5):408-412; Chem. Abstr., 111, p. 385, Abstr. No. 83960x (1989).
Stewart et al; "Stability of Cisplatin and Epotoside in Intravenous Admixture," Am. J. Hospit. Pharm., 46:1400-1404 (1989); Chem. Abstr., 111, p. 388, Abstr. No. 140313q (1989).
Aoki et al., "Antitumor Formulations Containing Etoposide," EPO Appl. 401,695; Chem. Abstr., 111, p. 388, Abstr. No. 150207j (1991); only Abstract provided.
Izawa et al; Chemical Abstracts 114:43481x (1991).

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