Freeze-dried blood cells, stem cells and platelets, and manufact

Details Freeze-dried blood cells, stem cells and platelets, and manufact Freeze-dried blood cells, stem cells and platelets, and manufact

1995-02-21

1997-08-12

Soderquist, Arlen

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Particle count or volume standard or control

436 8, 435 2, 435260, 34304, G01N 3100, A01N 102

Patent

active

056564988

ABSTRACT:
The present invention provides a method for manufacturing freeze-dried blood cells, stem cells and platelets comprising the steps of: pre-treating a liquid selected from the group consisting of blood including blood cells, bone marrow fluid (hemopoietic stem cells), and platelets in blood plasma, with a solution containing at least one substance selected from the group consisting of saccharide, biopolymer, acid and acid salt; conducting granulation of the aforementioned pre-treated liquid into a granules of a predetermined size; performing rapid cooling of the granules; and drying the resultant frozen material by sublimation of the water content contained therein.

REFERENCES:
patent: 3228838 (1966-01-01), Rinfret et al.
patent: 3928566 (1975-12-01), Briggs et al.
patent: 4329787 (1982-05-01), Newton
patent: 4874690 (1989-10-01), Goodrich, Jr. et al.
patent: 5171661 (1992-12-01), Goodrich, Jr. et al.
patent: 5364756 (1994-11-01), Livesey et al.
"Cryogenec Preservation of Erythrocytes by a Droplet Freezing Technique", Journal of Hokkaido University School of Medicine, T. Sato, vol. 58, No. 2, pp. 144-153 (1983).
Japanese Patent Application, Second Publication Hei 3-57831.

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