Free radical-catalyzed synthesis of benzoprostacyclins

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D30793

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active

051699591

ABSTRACT:
A method is provided for preparing benzoprostacyclins by the free-radical-catalyzed tandem alkene insertion into a 1,4-bisoxy-substituted cyclopent-2-ene intermediate.

REFERENCES:
patent: 4230879 (1980-10-01), Wissner et al.
patent: 4301164 (1981-11-01), Ohno et al.
patent: 4474802 (1984-10-01), Ohno et al.
patent: 4590014 (1986-05-01), Wolf et al.
Aldrichimica Acta, Aldrich Chemical Co. Inc., Milwaukee, WI (publisher), vol. 16, at p. 14, (1983).
T. Bargar et al., J. Med. Chem., 29, 313 (1986).
W. Bartmann et al., Agnew. Chem. Int. Ed. Eng., 21, 751 (1982).
G. Born, Nature, 194, 927 (1962).
D. Deardorff et al., Tetrahedron Lett., 26, 5615 (1984).
J. Fried et al., Ann. N.Y. Acad. Sciences, 38, 180 (1971).
R. Johnson et al., Prostaglandins, 12, 915 (1976).
M. Jung et al., Tetrahedron Lett., 23, 3851 (1982).
G. Keck et al., J. Org. Chem., 52, 2958 (1987).
R. Larcock et al., Tetrahedron Lett., 43, 2013 (1987).
M. Midland et al., Organic Synthesis, 63, 57 (1984).
S. Moncada et al., Nature, 263, 663 (1976).
H. Nagase et al., Tetrahedron Lett., 31, 4493 (1990).
R. Newton et al., Synthesis, 449 (1984).
R. Noyori et al., J. Am. Chem. Soc., 106, 6717 (1984).
M. Ochiai et al., Tetrahedron Lett., 24, 4025 (1983).
K. Ohno et al., Tetrahedron Lett., 31, 4485 (1990).
K. Parker et al., Tetrahedron Lett., 27, 2833 (1986).
G. Russell et al., J. Am. Chem. Soc., 106, 4622 (1984).
G. Russell et al., Organometallics, 7, 696 (1988).
K. Shankaran et al., Tetrahedron Lett., 26, 6001 (1985).
W. Skubala, J. Med. Chem., 29, 313 (1986).
C. Sloan et al., Tetrahedron Lett., 29, 4685 (1988).
J. Stille, Agnew. Chem. Int. Ed. Engl., 25, 508 (1986).
G. Stork et al., J. Am. Chem. Soc., 108, 6385 (1986).
M. Suzuki et al., Tetrahedron, 46, 4809 (1990).
T. Umetsu et al., Japan J. Pharmacol., 43, 81 (1987).
C. Walling, Tetrahedron Symp., 41, 3887 (1985).
Larock and Lee, J. Org. Chem., vol. 56, pp. 6253-6254 (1991).

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