Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-11
2011-10-04
Badio, Barbara P (Department: 1628)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
08030482
ABSTRACT:
The present invention relates to free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy to visualize the exchange, distribution, and trafficking of free cholesterol between living cells and to monitor the movement of free cholesterol between ordered and disordered lipid domains in membranes.
REFERENCES:
Shaw et al., “Correlated Fluorescence-Atomic Force Microscopy of Membrane Domains: Structure of Fluorescence Probes Determines Lipid Localization.” Biophysical Journal, vol. 90, pp. 2170-2178, Mar. 2006.
Li et al., “First Synthesis of Free Cholesterol—BODIPY Conjugates,”J. Org. Chem., 71, 1718-1721 (2006).
Shaw et al., “Correlated Fluorescence-Atomic Force Microscopy of Membrane Domains: Structure of Fluorescence Probes Determines Lipid Localization,”Biophysical Journal, 90, 2170-2178 (2006).
Shaw, et al., “Tracking peptide-membrane interactions: Insights from in situ coupled confocal-atomic force microscopy imaging of NAP-22 peptide insertion and assembly,”Journal of Structural Biology, 155, 458-469 (2006).
Bittman Robert
Li Zaiguo
Badio Barbara P
Hoffman & Baron LLP
Research Foundation of the City University of New York
LandOfFree
Free cholesterol analogs bearing a boron dipyrromethene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Free cholesterol analogs bearing a boron dipyrromethene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Free cholesterol analogs bearing a boron dipyrromethene... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4257145