Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means
Reexamination Certificate
2007-06-05
2007-06-05
Wells, Nikita (Department: 2881)
Radiant energy
Ionic separation or analysis
Cyclically varying ion selecting field means
C250S282000, C250S281000, C250S290000, C250S293000
Reexamination Certificate
active
10508950
ABSTRACT:
In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.
REFERENCES:
patent: 4861988 (1989-08-01), Henion et al.
patent: 4963736 (1990-10-01), Douglas et al.
patent: 5248875 (1993-09-01), Douglas et al.
patent: 5679950 (1997-10-01), Baba et al.
patent: 6111250 (2000-08-01), Thomson et al.
patent: 6121607 (2000-09-01), Whitehouse et al.
patent: RE36906 (2000-10-01), Franzen et al.
patent: 6177668 (2001-01-01), Hager
patent: 6483109 (2002-11-01), Reinhold et al.
patent: 6504148 (2003-01-01), Hager
patent: 6703607 (2004-03-01), Stott et al.
patent: 6720554 (2004-04-01), Hager
patent: 2003/0189168 (2003-10-01), Londry et al.
patent: 2003/0189171 (2003-10-01), Londry et al.
patent: 2004/0011956 (2004-01-01), Londry et al.
patent: 567276 (1993-04-01), None
Marshall et al., 1998. “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: A Primer”. Mass Spectrometry Reviews 17:1-35.
Dawson, P.H., 1980. “Ion Optical Properties of Quadrupole Mass Filters”. Advances in Electronics and Electron Physics 53:153-208.
International Search Report of PCT/CA2003/00477 (published as WO 03/088305).
Collings Bruce A.
Londry Frank
Stott William R.
Hunt John
Marquardt Matthew
MDS Inc.
Torys LLP
Wells Nikita
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