Fragment of TNF-.alpha. for promoting wound healing

Details Fragment of TNF-.alpha. for promoting wound healing Fragment of TNF-.alpha. for promoting wound healing

1991-05-07

1992-11-03

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, A61K 3700, A61K 4505

Patent

active

051604833

ABSTRACT:
A method and composition for promoting the healing of an open wound, such as a fresh surgical incision, a decubitus ulcer, or a diabetes ulcer. The method includes applying to the wound a therapeutically effective amount of a composition comprising a protein fragment of tumor necrosis factor .alpha.(TNF-.alpha.) including amino acids 31 through 68 SEQ ID NO.: 1. The composition may be applied topically or injected locally into a wound or ulcer site. A preferred composition includes a carrier medium selected from sterile water, sterile saline, and albumin. Topical formulations are administered as sprays, gels, ointments or salves.

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Abstract--Human Recombinant Tumor Necrosis Factor Alpha Is a Fibroblast Chemoattractant--Arnold E. Postlethwaite--Clinical Research vol. 38, No. 2, 1990, 478A.
Stimulation of Fibroblast Chemotaxis by Human Recombinant Tumor Necrosis Factor Alpha (TNF-Alpha) and a Synthetic TNF-Alpha 31-68 Peptide Arnold E. Postlethwaite and Jerome M. Seyer The Journal of Experimental Medicine--vol. 172--Dec., 1990, 1749-1756.

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