Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-10-10
2006-10-10
Li, Bao Qun (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C536S023100, C536S023700, C536S023720, C435S069100, C435S091100, C435S093000, C435S243000, C435S245000, C435S252200
Reexamination Certificate
active
07119167
ABSTRACT:
The present invention relates to a 2227-bp DNA fragment that confers antiphage activity. Two proteins encoded by this DNA sequence are responsible for the phage resistance phenotype. When introduced inLactococcus lactisphage-sensitive strain, this DNA fragment aborts infection of phages of the 936 and P335 species.
REFERENCES:
patent: 4931396 (1990-06-01), Klaenhammer et al.
patent: 5019506 (1991-05-01), Daly et al.
patent: 5591631 (1997-01-01), Leppla et al.
patent: 5593885 (1997-01-01), Klaenhammer et al.
patent: 5824523 (1998-10-01), Moineau et al.
patent: 5928688 (1999-07-01), Moineau et al.
patent: 5994118 (1999-11-01), Moineau et al.
patent: WO 97 20917 (1997-06-01), None
Sequence comparision results
Allison G. E. et al., (1998)Phage resistance mechanisms on lactic acid bacteria, Int. Dairy J. 8: 207-226.
Moineau S., (1999)Applications of phage in lactic acid bacteria,Antonie van Leeuwenhoek 76: 377-382.
Bouchard J.D. et al.,Characterization of a novel phage resistence mechanism in Lactococcus lactis, J. Anim. Sci., vol. 78, Suppl 1/J. Dairy Sci., vol. 83, Suppl. 1/2000.
O'Connor L. et al.,AbiG, a genotipically novel abortive infection machanism encoded by plasmid pC1750 of Lactococcus lactis subsp. Cremoris US653,Applied and Envir. Microb. Washington D.C. US, col. 62, No. 9, Sep. 1996, pp. 3075-3082.
Su P et al.,Isolation, cloning and characterization of the abil gene from Lactococcus lactis subsp. Lactis M138 encoding abortive phage infection,J. of Biotechnology, Elsevier Science Publishers, Amsterdam, NL, vol. 54, No. 2, Apr. 25, 1997, pp. 95-104.
Brinboim, H. C.,A Rapid Alkaline Extraction Method for the Isolation of Plasmid DNA,1983, Method Enzym. 100:243-255.
O'Sullivan, D. J. et al.,Rapid Mini-Prep of High-Quality Plasmid DNA from Lactococcus and Lactobacillus spp.,1993 Appl. Environ. Microbiol. vol. 59, No. 8, 2730-2733.
Hill et al.,Rapid Method To Characterize Lactocuccal Bacteriophage Genomes,1991, Appl. Environ. Microbiol. vol. 57, No. 1, 283-288.
Altschul et al.,Gapped BLAST and PSI-BLAST: a new generation of protein search programs,1997, Nuc. Acids Res. 25 : 3389-3402.
Sanders el al.,Restriction and Modification in Group N Streptococci : Effect of Heat on Development of Modified Lytic Bacteriophage,1980, Appl. Environ. Microbiol. vol. 40, No. 3, 500-506.
Behnke et al.,Bacteriophage Interference in Streptococcus pyogenes,1978, Virology 85 : 118-128.
Moineau et al.,Differentiation of Two Abortive Mechanisms by Using Monoclonal Antibodies Directed toward Lactococcal Bacteriophage Capsid Proteins,1993, Appl. Environ. Microbiol. vol. 59, No. 1, 208-212.
Von Heijne G.,Membrane Protein Structure Prediction: Hydrophobicity Analysis and the Positive-inside Rule, 1992, J. Mol. Biol. 225: 487-494.
Holo H. et al.,High-Frequency Transformation, by Electroporation, of Lactococcus lactis subsp. Cremoris Grown woth Glycine in Osmotically Stabilized Media,1989, Appl. Environ. Microbiol. 55 : 3119-3123.
DATABASE EMBL Online EBI, Feb. 20, 1998,Lactococcus lactis subsp. Cremoris plasmid pNZ4000, complete sequence,Database accession No. AF036485 XP002207905.
DATABASE EMBL Online EBI, Aug. 10, 2000,Lactococcus lactis subsp. Cremoris plasmid pAH82, complete sequence,Database accession No. AF243383 XP 002207906.
GenBank database (accession No. AF483000).
Bouchard Julie
Dion Éric
Moineau Sylvain
Li Bao Qun
Ogilvy Renault LLP
Universite Laval
LandOfFree
Fragment of L. lactis plasmid conferring antiphage activity... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fragment of L. lactis plasmid conferring antiphage activity..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fragment of L. lactis plasmid conferring antiphage activity... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3631094