Fractionation/purification of plasma by ion exchange chromatogra

Details Fractionation/purification of plasma by ion exchange chromatogra Fractionation/purification of plasma by ion exchange chromatogra

1984-04-02

1987-06-23

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530380, 530416, 530417, 424101, 210661, 210666, 210263, 210290, 210927, A61K 3702, B01D 1506

Patent

active

046753842

ABSTRACT:
The plasma proteins contained in a plasma solution thereof are chromatographically fractioned, e.g., to obtain a high purity therapeutic grade albumin product, by successively contacting said plasma solution with at least one anion exchanger and at least one cation exchanger in fixed bed chromatography columns, the contact and exchange medium of chromatography therein also comprising a plurality of at least partially hydrophobic support particulates and a plurality of hydrophilic ion exchanger support particulates.

REFERENCES:
patent: 3941718 (1976-03-01), Barabas et al.
patent: 4025500 (1977-05-01), Garcia et al.
patent: 4086222 (1978-04-01), Lindquist et al.
patent: 4136094 (1979-01-01), Condie
patent: 4176056 (1979-11-01), Grier
patent: 4228154 (1980-10-01), Fisher et al.
patent: 4229342 (1980-10-01), Mirabel
patent: 4308254 (1981-12-01), Tayot et al.

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