Fractionation of proteins

Details Fractionation of proteins Fractionation of proteins

1980-01-14

1981-01-20

Prescott, Arthur C.

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

204299R, 23230B, 424 12, G01N 2726, A61K 3514, A61K 3516

Patent

active

042460859

ABSTRACT:
The invention is concerned with fractionation of proteins, in particular with fractionation of immunoglobulin containing solutions, such as blood plasma, by continuous flow electrophoresis.
Hitherto, such solutions have been fractionated by ethanol precipitation methods (e.g. the Cohn Method). Such methods separate the IgG component of immunoglobulins but cannot separate the useful IgM component. In the invention, the solutions are fractionated by continuous flow electrophoresis at a pH of between 7 and 8.4 and an electrical conductivity of between 1 and 2 mScm.sup.-1, thereby giving rise to fractions containing particular combinations of immunoglobulin components (IgG, IgM, IgA, IgD and IgE) with potentially valuable properties.

REFERENCES:
patent: 3870617 (1975-03-01), Bovrat
patent: 3989613 (1976-11-01), Gritzner
patent: 4149957 (1979-04-01), Gibson et al.
Chem. Abstracts, vol. 54, No. 1, 1-10-60, col. 672(b).
Chem. Abstracts, vol. 52, No. 21, 11-10-58, col. 18751 (g,h).

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