Fractionation of protein mixtures

Details Fractionation of protein mixtures Fractionation of protein mixtures

1980-12-15

1982-09-28

Williams, Howard S.

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

B01D 5702

Patent

active

043517102

ABSTRACT:
This invention relates to the separation of complex protein mixtures by lowering (desalting) or by raising (salting-out) their electrolytic (ionic) concentration by electrodialysis followed by chilling, pH adjustment, filtration, and/or centrifugation and optionally thereafter restoration of the lost electrolyte or removal of the gained electrolyte and water. This technique is especially adaptable for therapeutic plasma exchange performed in situ for immunepheresis i.e. removal of globulin or immunecomplexes implicated in autoimmune diseases. The techniques are also applicable for antihemophilic factor separation and purification, and separation of proteins from whey.

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