Fractionation of heparin

Details Fractionation of heparin Fractionation of heparin

1982-09-29

1984-05-01

Schain, Howard E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 11, C08B 3710, A61K 31725

Patent

active

044463146

ABSTRACT:
A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein. In this manner, heparin can be fractionated into high activity and low activity components.

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patent: 4087415 (1978-05-01), Bick et al.
patent: 4119774 (1978-10-01), Andersson et al.
patent: 4289747 (1981-09-01), Chu
patent: 4301153 (1981-11-01), Rosenberg
patent: 4371515 (1983-02-01), Chu
Febs Letters, vol. 66, 1976, Hook et al., pp. 90-93.
J. of Biol. Chem., vol. 254, 1979, Nexo et al., pp. 8740-8743.
Biochemical & Biophysical Research Communications, vol. 69, 1976, Lam et al., pp. 570-577.
Proc. Natl. Acad. Sci-USA, vol. 75, No. 7, pp. 3065-3069, 1978, Rosenberg et al.
Biochemical & Biophysical Research Communications, vol. 86, 1979.
Rosenberg et al., pp. 1319-1324.

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