Liquid purification or separation – Recirculation – Serially connected distinct treating or storage units
Patent
1984-04-19
1986-11-25
Fisher, Richard V.
Liquid purification or separation
Recirculation
Serially connected distinct treating or storage units
210201, 210205, 2102571, 210258, 2103601, 210927, B01D 3600
Patent
active
046247807
ABSTRACT:
There is provided in accordance with practice of this invention a process for separating protein fractions from a solution containing proteins and an apparatus for practicing the process. The process and apparatus involve withdrawing from a suspension tank a portion of the suspension contained therein to form a recycle stream. The withdrawn suspension forming the recycle stream contains particles of a selected protein fraction precipitated from a solution containing proteins. Fresh protein solution comprising proteins of the selected protein fraction is mixed into the recycle stream to form a mixed recycle stream. At least a portion of the selected protein fraction proteins in the fresh protein solution precipitate onto previously precipitated selected protein fraction particles suspended in the mixed recycle stream. The mixed recycle stream is introduced back into the suspension tank. A portion of the suspension is withdrawn from the suspension tank in a product stream and precipitated, selected protein fraction particles are recovered from the product stream.
REFERENCES:
patent: 2390074 (1945-12-01), Cohn
patent: 3764009 (1973-10-01), Watt
patent: 4066549 (1978-01-01), Oeser et al.
patent: 4067863 (1978-01-01), Watt
patent: 4379083 (1983-04-01), Falke et al.
E. J. Cohn et al., Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids, The Journal of the American Chemical Society, vol. LXVIII, (Jan.-Jul. 1946), pp. 459-475.
Alpha Therapeutic Corporation
Fisher Richard V.
Jones W. Gary
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