Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1979-09-17
1981-06-09
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
260112B, A61K 3514, C07G 700
Patent
active
042725232
ABSTRACT:
The present invention relates to a method for making fibrinogen, a prothrombin complex containing the coagulation factors II, VII, IX and X that can contain antithrombin III, antithrombin III and a solution of stable serum proteins from a blood plasma stabilized with citrate which is characterized in that from the plasma, by adsorption on colloidal silica of a specific surface of 50 to 400 m.sup.2 /g and a concentration of 50 to 400 mg per g plasma protein, fibrinogen is isolated; and in that thereupon (a) citrate and calcium ions are removed by ultrafiltration or dialysis and then from the protein solution, over anion exchangers or tricalcium phosphate that adsorb proteins, the coagulation factors II, VII, IX and X and antithrombin III are adsorbed, or (b) the coagulation factors II, VII, IX and X are adsorbed prior to the ultrafiltration or dialysis, antithrombin III then not being simultaneously adsorbed, and antithrombin III is adsorbed on the said adsorbents after the removal of the citrate and calcium ions by ultrafiltration or dialysis; and in that thereupon from the remaining plasma fluid further unstable proteins are removed by another adsorption on colloidal silica and a solution of stable serum proteins is obtained.
REFERENCES:
patent: 3652530 (1972-03-01), Johnson et al.
patent: 3682881 (1972-08-01), Fekete et al.
patent: 3869436 (1975-03-01), Falksneden
patent: 3916026 (1975-10-01), Stephan
patent: 3920625 (1975-11-01), Anderson et al.
patent: 3973002 (1976-08-01), Hagan et al.
Laursen et al., Chem. Abstr. 67,50,325 (1967).
Reid et al., Ind. & Eng. Chem. 43, No. 5 (1951) 1074 & 1075.
Tullis et al., The New England Journal of Medicine 273, No. 13 (1965) 667-674.
Kotitschke Ronald
Stephan Wolfgang
Biotest Serum Institut GmbH
Phillips Delbert R.
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