Measuring and testing – Instrument proving or calibrating – Gas or liquid analyzer
Reexamination Certificate
2006-02-14
2006-02-14
Noland, Thomas P. (Department: 2856)
Measuring and testing
Instrument proving or calibrating
Gas or liquid analyzer
C702S100000
Reexamination Certificate
active
06997031
ABSTRACT:
A method and apparatus for controlling fraction collection in an eluent stream flowing from an LC column. A triggering detector recognizes the presence of a target substance according to characteristics of chromatographic peaks in the eluent stream and initiates a delay timer to trigger the fraction collector. A waste stream detector is disposed at any distance from the fraction collector to detect peaks in the waste stream flowing from a fraction collector. The signature of fraction collector actuation is seen by the waste stream detector, permitting the delay time to be adjusted for optimal collection of the target compound. The presence or absence of a peak or the characteristics of a remnant peak detected by the waste stream detector are used to confirm that the target component of the eluent stream was collected as intended by the fraction collector.
REFERENCES:
patent: 3516577 (1970-06-01), Pitt
patent: 4971915 (1990-11-01), Schwartz et al.
patent: 5668735 (1997-09-01), Dominguez et al.
patent: 5987959 (1999-11-01), Klee et al.
patent: 6106710 (2000-08-01), Fischer et al.
patent: 6406633 (2002-06-01), Fischer et al.
patent: 6660149 (2003-12-01), Karger et al.
patent: 6691053 (2004-02-01), Quimby et al.
patent: 6767467 (2004-07-01), Fischer et al.
patent: 0 274 847 (1993-03-01), None
patent: 0 692 713 (1996-01-01), None
patent: 0 749 972 (1996-12-01), None
patent: 0 639 098 (1998-08-01), None
patent: 0 639 099 (1998-08-01), None
patent: 0 662 013 (1999-05-01), None
patent: 0 724 901 (2002-09-01), None
patent: 0 835 446 (2003-04-01), None
patent: 06-102246 (1994-04-01), None
patent: 11-258224 (1999-09-01), None
patent: WO 97/00877 (1997-01-01), None
patent: WO 99/05319 (1999-02-01), None
patent: WO 99/22228 (1999-05-01), None
A. Baj et al., “Qualitative and Quantitative Evaluation of Vaccinium Myrtillus Anthocyanins By High-Resolution Gas Chromatography and High-Performance Liquid Chromatography”,Journal of Chromatography,vol. 279, pps: 365-372, 1983, month not given.
W. Christie, “Separation of Molecular Species of Triacylglycerols by High-Performance Liquid Chromatography with a Silver Ion Column”,Journal of Chromatography;vol. 454; pps: 273-284; 1988, month not given.
Jos F. H. M. Brouwers et al., “Rapid separation and identification of phosphatidylethanolamine molecular species”,Journal of Lipid Research,vol. 40, pps: 164-169, 1999, month not given.
William W. Christie, et al., “Separation of Picolinyl Ester Derivatives of Fatty Acids by High-Performance Liquid Chromatography for Identification by Mass Spectrometry”, Journal of Chromatography, vol. 392, pps. 259-265, 1987, month not given.
Ewa Dolecka, et al., “Variable Splitter for Regulation of the Solvent Evaporation Rate in the Coupling of Liquid Chromatography with Gas Chromatography,”Journal of High Resolution Chromatography,vol. 13, pps. 405-409, Jun. 1990.
J. N. Driscoll, et al., “Trace Analysis of Organic Compounds by High-Performance Liquid Chromatography with Photoionization Detection”,Journal of Chromatography,vol. 302, pps. 43-50, 1984, month not given.
Timothy G. Heath, et al., “Reversed-phase capillary high-performance liquid chromatography with on-line UV, fluorescence and electrospray ionization mass spectrometric detection in the analysis of peptides and proteins”,Journal of Chromatographyvol. 638, pps. 9-19, 1993, month not given.
Tony Herlt, “A Facile Separation of Nonactin and its Homologues”,J. Liq. Chrom. & Rel. Technol.,vol. 20(8), pps. 1295-1300, 1997, month not given.
Masanori Hori, et al., “Molecular Species Analysis of Polyunsaturated Fish Triacylglycerol by High-Performance Liquid Chromatography/Fast Atom Bombardment Mass Spectrometry”,Analytical Sciences,vol. 10, pps. 719-724, Oct. 1994.
Fong-Fu Hsu, et al., “Preparative high-performance liquid chromatography using detection by thermospray mass spectrometry”,Journal of Chromatography,vol. 478, pps. 429-432, 1989, month not given.
Sheri L. Jordan, et al., “Identification of an anti-bacterial agent in toothpaste via liquid chromatography—Fourier transform infrared spectrometry mobile phase elimination”,Journal of Chromatography A,vol. 755, pps. 211-218, 1996, month not given.
P. Juanéda, et al., “Separation and Quantification of Heart and Liver Phospholipid Classes by High-Performance Liquid Chromatography Using a New Light Scattering Detector”,LIPIDS,vol. 25, pps. 756-759, 1990, month not given.
Jeffrey P. Kiplinger, et al., “Structure-controlled Automated Purification of Parallel Synthesis Products in Drug Discovery”,Rapid Commun. Mass Spectrom,vol. 12, pps. 658-664, 1998, month not given.
P. Kokkonen, et al., “Separation and Identification of Intact Glucosinolates Using Direct Coupling of High-performance Liquid Chromatography with Frit to Fast-atom Bombardment Mass Spectrometry”,Rapid Communications in Mass Spectrometry,vol. 3, No. 4, pps. 102-106, 1989, month not given.
Mihály Kotrebai, et al., “Identification of the principal selenium compounds in selenium-enriched natural sample extracts by ion-pair liquid chromatography with inductively coupled plasma- and electrospray ionization-mass spectrometric detection”,Anal. Commun.,vol. 36, pps. 249-252, 1999, month not given.
Zhaoyang Li, et al., “A subnanogram API LC/MS/MS quantitation method for depsipeptide FR901228 and its preclinical pharmacokinetics”,J. Pharm. Biomed. Anal,vol. 22, pps. 33-44, 2000, month not given.
Jinping Liu, et al., “Miniaturized HPLC and ionspray mass spectrometry applied to the analysis of Paclitaxel and taxanes”,Journal of Pharmaceutical and Biomedical Analysis,vol. 15, pps. 1729-1739, 1997, month not given.
Arjan J. H. Louter, et al., “On-line Solid-Phase Extraction-Thermal Desorption-Gas Chromatography with Ion Trap Detection Tandem Mass Spectrometry for the Analysis of Microcontaminants in Water”,J. High Resol. Chromatogr.,vol. 19, pps. 679-685, Dec. 1996.
Eric D. Lund, et al., “A stream splitter for liquid chromatography”,J. Chromatog,vol. 31, pps. 549-550, 1967, month not given.
F. A. Maris, et al., “On-line Trace Enrichment for Improved Sensitivity in Liquid Chromatography with Direct Liquid Introduction Mass Spectrometric Detection”,Journal of Chromatography,vol. 323, pps. 113-120, 1985, month not given.
B. Pacciarelli, et al., “GC Column Effluent Splitter for Problematic Solvents Introduced in Large Volumes: Determination of Di-(2-ethylhexyl) Phthalate in Triglyceride Matrices as an Application”,Journal of High Resolution Chromatography & Chromatography Communications,vol. 11, pps. 135-139, Jan. 1988.
Thomas V. Raglione, et al., “Liquid Chromatography-Gas Chromatography Interfacing Using Microbore High-Performance Liquid Chromatography with a Bundled Capillary Stream Splitter”,Analytical Chemistry,vol. 58, No. 13, pps. 2680-2683, Nov. 1986.
Thomas V. Raglione, et al., “On-line Microbore High-Performance Liquid Chromatography-Capillary Gas Chromatography-Mass Spectrometry”,Journal of Chromatography,vol. 409, pps. 205-212, 1987, month not given.
Herbert S. Rosenkranz, et al., “A Study on the Absorption of Nucleic Acids by Charcoal”,Journal of Chromatography,vol. 30, pps. 549-555, 1967, month not given.
Dr. Ashley B. Sage, “High Throughput Characterisation & Purification of Combinatorial Synthetic Arrays by LC-UV-MS”, Micromass UK Ltd, UK., 12 pps., by Feb. 2005.
Urban Skogsberg, et al., “Liquid chromatography-electrospray mass spectrometry method to separate and detect N-tert.-butoxycarbonyl peptides”,J. Chromatogr. A.,vol. 808, pps. 253-256, 1998, month not given.
F. Valero, et al., “Biomass Estimation Using On-Line Glucose Monitoring by Flow Injection Analysis”,Applied Biochemistry and Biotechnology,vol. 24/25, pps. 591-602, 1990, month not given.
F.
Craze Andrew Simon
Gilby Anthony
Brown Rudnick Berlack & Israels LLP
Michaelis Brian L.
Noland Thomas P.
Waters Corporation
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