Fowl bone mineralization with 28-NOR 1.alpha.-hydroxyvitamin D.s

Details Fowl bone mineralization with 28-NOR 1.alpha.-hydroxyvitamin D.s Fowl bone mineralization with 28-NOR 1.alpha.-hydroxyvitamin D.s

1985-10-03

1988-01-12

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

047192046

ABSTRACT:
The invention provides, as novel vitamin D derivatives, analogs of vitamin D.sub.2 compounds which lack the 24-methyl substituent and are identified as 1.alpha.-hydroxy-28-norvitamin D.sub.2 and 1.alpha.,25-dihydroxy-28-norvitamin D.sub.2.
The compounds of the invention are characterized by unexpectedly high vitamin D-like activity as well as a novel activity pattern. Because of such activity they would find ready application as substitutes for vitamin D or various of the known vitamin D metabolites in their various application for the treatment of calcium disorders.

REFERENCES:
patent: 4225596 (1980-09-01), DeLuca
patent: 4508651 (1985-04-01), Baggiolini et al.
patent: 4554105 (1985-11-01), Hesse

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