Fosinopril tablet formulations

Details Fosinopril tablet formulations Fosinopril tablet formulations

1990-06-26

1991-04-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424456, 424464, 424488, 424490, 424494, A61K 920

Patent

active

050063448

ABSTRACT:
Shelf stable tablets containing fosinopril sodium are prepared by employing either sodium stearyl fumarate or hydrogenated vegetable oil as the lubricant. The tablets can contain conventional excipients such as fillers, binders, and disintegrants as well as an optional diuretic.

REFERENCES:
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4384123 (1983-05-01), Petrillo, Jr.
patent: 4793998 (1988-12-01), Murthy et al.
patent: 4803081 (1989-02-01), Falk
patent: 4832957 (1989-05-01), Dempski
patent: 4900755 (1990-02-01), Dempski
Holzer et al., "Evaluation of Some Lubricants by the Comparison of Friction Coefficients and Tablet Properties", Acta Pharm. Suec., vol. 18, pp. 139-148 (1981).
Holzer et al., "Evaluation of Sodium Stearyl Fumarate as a Tablet Lubricant", Int. Journ. of Pharmaceutics, vol. 2, 145-153 (1979).
Lindberg, "Evaluation of Some Tablet Lubricants", Acta Pharm. Suec., vol. 9, pp. 207-214 (1972).
Shah et al., "Evaluation of Two New Lubricants . . . ", Drug Development and Industrial Pharmacy, vol. 12, pp. 1329-1346 (1986).
Chowhan et al., "Drug-Excipient Interactions . . . ", Jour. of Pharmaceutical Sciences, vol. 75, pp. 542-545 (1986).

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