Formulations with hydrophobic permeation enhancers

Details Formulations with hydrophobic permeation enhancers Formulations with hydrophobic permeation enhancers

1993-05-20

1997-05-13

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424449, 514944, 514946, 514951, A61K 906

Patent

active

056290195

ABSTRACT:
This invention is directed to a novel formulation for effectively utilizing hydrophobic permeation enhancers for the increased permeability of active agents through the skin or mucosa along with reduction of the lag time between application of the active agent and attainment of a therapeutically effective agent flux, with little or no irritation to the host. The invention is directed to compositions containing a hydrophobic permeation enhancer, which permeation enhancer has been micronized and stabilized in an inert carrier such as water. These compositions can be combined with a biologically active agent to provide enhanced permeability of the active agent to the skin or mucosa.

REFERENCES:
patent: 4746515 (1988-05-01), Cheng et al.
patent: 4778678 (1988-10-01), Guse et al.
patent: 4863738 (1989-09-01), Taskovich
patent: 4882163 (1989-11-01), Guse et al.
patent: 4946853 (1990-08-01), Bannon et al.
Dialog Information Services, File 351, WPIL, Dialog Access. No. 008655304, WPI Acces. No. 91-159331/22, Yg Nonogawa Shoji: "Drug for extgernal dermal use-contains active drug, e.g. indomethacin, enveloped . . . ".
Dialog Information Services, File 155, Medline, Dialog Access. No. 07981724, Medline Access No. 92119724, Wearley LL: "Recent Progress in Protein and Peptide Delivery by Noninvasive Routes".

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