Formulations to increase in vivo survival of probiotic...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Preserving or maintaining micro-organism

Reexamination Certificate

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Details

C435S243000, C435S252900, C424S278100

Reexamination Certificate

active

11415894

ABSTRACT:
Disclosed is a formulation for preserving the life of probiotic bacteria during passage through the stomach, while permitting their release in the intestine, and which has a low water activity and correspondingly long shelf life. These formulations are designed to retain potency up to the product expiration date. The formulation includes a substantially water-free mixture of probiotic bacteria with monovalent alginate salts, wherein the mixture has been formed and is maintained in a substantially water-free environment. The alginate salts include sodium-alginate and potassium alginate, but not divalent salts such as magnesium alginate or calcium alginate. Generally, an enteric coating (e.g., gelatin or cellulose encapsulation) for the formulation is provided.

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patent: 6033887 (2000-03-01), Charpentier
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patent: 6455052 (2002-09-01), Marcussen et al.
patent: 6531152 (2003-03-01), Lerner et al.
patent: 6632457 (2003-10-01), Sawhney
patent: 2003/0165472 (2003-09-01), McGrath et al.

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