Formulations providing three distinct releases

Details Formulations providing three distinct releases Formulations providing three distinct releases

1986-03-04

1988-03-01

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424453, 424457, 424459, 424461, 424462, A61K 952, A61K 954, A61K 958

Patent

active

047285125

ABSTRACT:
A therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pH independent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids.
The therapeutic preparation may be utilized as a mixture of groups of spheroids in a capsule.

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F. W. Goodhart et al, Pharmaceutical Technology, pp. 64-71, Apr. 1984.

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