Formulations of hydrophobic proteins in an immunogenic...

Details Formulations of hydrophobic proteins in an immunogenic... Formulations of hydrophobic proteins in an immunogenic...

2004-12-28

2009-10-27

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

C424S009100, C424S009200

Reexamination Certificate

active

07608278

ABSTRACT:
The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured in the rat footpad model as compared to said first composition.

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Waite, Douglas C.; et al, Vaccine 19:3957-3967 (2001).
Jeurissen SH M et al; Infection and Immunity, 55(1):253-257 (1987).

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