Formulations of heterocyclic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3152

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049635557

ABSTRACT:
A topical pharmaceutical formulation for use in treating virus infections of the skin or mucosa and containing 9-(2-hydroxyethoxymethyl) guanine or a salt or ester thereof which comprises a dispersed oil phase and a continuous aqueous phase containing therein water, at least 30% of a polyhydric alcohol (by weight of the formulation) and solublized acyclovir.

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patent: 3924004 (1975-12-01), Chang
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patent: 4141976 (1979-02-01), Voorhees
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Katz et al, J. Soc. Cosmet. Chem., 23(9), 565-590, (1972).
Concepts in Biochemical Pharmacology, Ed. Brodie & Gillette, 1971 Chp. 7 Katz & Poulsen.
B. J. Poulsen, et al., J. of Pharm. Sci., pp. 928-933, vol. 57, No. 6, Jun. 1968, Effect of Topical Vehicle Composition on the in Vitro Release of Fluocinolone.
M. K. Polano, et al., Arch Dermatol, vol. 112, May 1976, pp. 675-680, Dependence of Corticosteroid Penetration of the Vehicle.
J. Ostrenga, et al., J. of Pharm. Sci., pp. 1175-1179, vol. 60, No. 8, Aug. 1971, Significance of Vehicle Composition I: Relationship Between Topical Vehicle Composition, Skin Penetrability, and Clinical Efficacy.

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