Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1987-03-27
1989-04-25
Kight, John
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
514690, A61K 3112, A61K 31685, A61K 3748
Patent
active
048246697
ABSTRACT:
The present invention comprises a stable and non-toxic coenzyme Q.sub.10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q.sub.10. Clinically effective blood levels of coenzyme Q.sub.10 are generally agreed to be between about 2 ug/ml and about 4 ug/ml. The formulation consists essentially of a clinically accepted fatty emulsion having an oil phase and coenzyme Q.sub.10 dissolved in the oil phase. The formulation preferably contains coenzyme Q.sub.10 at a level between about 7.5 ug/ml and about 30 ug/ml. The clinically accepted fatty emulsion comprises at least one vegetable oil, preferably corn oil, peanut oil, safflower oil, olive oil or soybean oil.
REFERENCES:
patent: 4068003 (1978-01-01), Miyata
patent: 4156718 (1979-05-01), Blizhakov
patent: 4325942 (1982-04-01), Taki et al.
patent: 4483873 (1984-11-01), Ohashi et al.
patent: 4617187 (1986-10-01), Okuyama et al.
Lucker, et al., Biomedical and Clinical Aspects of Coenzyme Q, vol. 4:143-151 (1984).
Sunamori, et al., Biomedical and Clinical Aspects of Coenzyme Q, 54:333-342 (1984).
Turco and King, Remington Pharmaceutical Sciences, 16th Edition, pp. 1488-1497 (1980).
Yamaguchi, J. Pharm. Pharmacol., 36:768 -769 (1984).
Eisai, Co. Ltd., Chem. Abstracts, 100:367, No. 100, Abstract No. 145017d (1984).
European Patent Application Publication No. 0132821.
Folkers, C. & En., Apr. 21, 1986, pp. 27-56.
Yamaguchi, Pharmaceuticals, 102:473, Abstract No. 32098d (1985).
Kanazawa and Takahashi, Biomedical and Clinical Aspects of Coenzyme Q, 3:31-42 (1981).
Kishi, et al., Biomedical and Clinical Aspects of Coenzyme Q, 3:67-78 (1981).
Page, et al., Archives Biochem. Biophy., 85:476 (1980).
Folkers Karl
Muratsu Kazumasa
Board of Regents , The University of Texas System
Kight John
Nutter Nathan M.
LandOfFree
Formulations of coenzyme Q.sub.10 for intravenous use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Formulations of coenzyme Q.sub.10 for intravenous use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Formulations of coenzyme Q.sub.10 for intravenous use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1194878