Formulations of blood clot-polymer matrix for delivery of osteog

Details Formulations of blood clot-polymer matrix for delivery of osteog Formulations of blood clot-polymer matrix for delivery of osteog

1991-10-11

1992-12-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424484, A61K 31765

Patent

active

051715791

ABSTRACT:
A composition comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; and an osteogenic protein-sequestering amount of blood clot.

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Hollinger, J., J. of Biomed. Mat. Res. 17:71-82 (1983).
Wood, D., Int. J. of Pharm. 7:1-18 (1980).
Kitchell, J. et al., Methods in Enzymology 112:436-448 (1985).
Johnson, E. et al., J. Jpn. Orthop. Assoc. 63:613-620 (1989).
Ferguson, D. et al., Clin. Ortho, and Related Res. 219:251-258 (1987).

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