Formulations of anthraquinone derivatives

Details Formulations of anthraquinone derivatives Formulations of anthraquinone derivatives

2007-10-02

2007-10-02

Powers, Fiona T (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C552S246000, C552S247000

Reexamination Certificate

active

11433545

ABSTRACT:
A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4alkyl groups and C2-4hydroxyalkyl and C2-4dihydroxyalkyl groups, or R′ and R″ together are a C2-6alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKain the range of −3.0 (minus 3.0) to 9.0

REFERENCES:
patent: 5132327 (1992-07-01), Patterson
patent: 6320063 (2001-11-01), Denny et al.
patent: 2237283 (1991-05-01), None
patent: WO91/05824 (1991-05-01), None
patent: WO 00/05194 (2000-02-01), None
patent: WO 2005/025537 (2005-03-01), None
Patterson, et al;British Journal of Cancer; 82(12), 1984-1990, 2000.
Patterson, et al;British Journal of Cancer; 83(12), 1589-1593, 2000.
Loadman, P.M., et al; “A Preclinical Pharmacokinetic Study of the Bioreductive Drug AQ4N”;Drug Metabolism and Disposition; vol. 29, No. 4 Part 1; pp. 422-426; (See pg. 423, col. 1, lines 13-16; Table 1) XP002306883 (2001).
Loadman, P.M., et al; “Separation methods for anthraquinone related anti-cancer drugs”;Journal of Chromatography B: Biomedical Sciences & Applications, Elsevier Science Publ, NL; vol. 764, No. 1-2, pp. 193-206 (whole document) XP004322153 (2001).
Lee, Ho H. et al.; “A Large-scale Synthesis of the Bioreductive Drug 1,4-Bis{′2-(dimethylamino)ethyl!amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide”;Journal of the Chemical Society, Perkin Transactions 1, 1999; pp. 2755-2758; XP002244552; Chemical Society, Letchworth., GB ISSN: 0300-922X.

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