Formulations for sustained-release of topical anesthetics and me

Details Formulations for sustained-release of topical anesthetics and me Formulations for sustained-release of topical anesthetics and me

1998-07-20

2000-06-13

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424484, 424485, 424486, 424 7802, 424 7803, 514817, 514900, 514902, A61K 950

Patent

active

060746742

ABSTRACT:
The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0.2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.

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