Formulations for delivery of drugs by metered dose inhalers with

Details Formulations for delivery of drugs by metered dose inhalers with Formulations for delivery of drugs by metered dose inhalers with

1991-02-14

1993-01-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

514653, 514784, 514970, A61K 912, A61K 31135, C07C 1908

Patent

active

051820978

ABSTRACT:
Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.

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Nelson et al., Alternative Formulations to Reduce CFC use in U.S. EPA Contract No. 68-02-4286.

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