Formulations for delivery of beclomethasone diproprionate by met

Details Formulations for delivery of beclomethasone diproprionate by met Formulations for delivery of beclomethasone diproprionate by met

1992-01-22

1993-04-13

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 43, 252305, A61L 904

Patent

active

052021106

ABSTRACT:
Beclomethasone diproprionate (BDP) forms a clathrate with HCFC-123, dimethyl ether (DME) and HCFC-141b which are less harmful propellants than the CFC propellants currently used in metered dose inhalers (MDIs). The clathrate can be remicronized and suspended for use in an MDI. BDP also is completely dissolved by DME based propellant blends and certain HCFC 123 propellant blends. Using propellant blends which completely dissolve BDP will assure more efficient dosing with an MDI.

REFERENCES:
patent: 4810488 (1989-03-01), Jinks

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