Formulations comprising olin 10-G to prevent particle aggregatio

Details Formulations comprising olin 10-G to prevent particle aggregatio Formulations comprising olin 10-G to prevent particle aggregatio

1992-12-10

1994-08-23

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 5, 424489, 424499, 514 5, 514718, 514975, A61K 914, A61K 31075

Patent

active

053405641

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having p-isononylphenoxypoly (glycidol) as a surface modifier adsorbed on the surface thereof. In preferred embodiments, the p-isononylphenoxypoly (glycidol) provides resistance to particle aggregation during heat sterilization. In another preferred embodiment, those nanoparticles also comprise a stability enhancing compound. A preferred stability enhancing compound is albumin. This invention further discloses a method of making nanoparticles having p-isononylphenoxypoly(glycidol) as a surface modifier adsorbed on the surface, comprised of contacting said nanoparticles with p-isononylphenoxypoly(glycidol) for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle. In a preferred embodiment, the p-isononylphenoxypoly (glycidol) surface modified nanoparticle is further contacted with a stability enhancing compound for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle with a stability enhancing compound associated therewith.

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