Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1994-10-24
1996-07-30
Page, Thurman
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424445, 424449, 424451, 424452, 424458, 424460, 424461, 424464, 424465, 424474, 424475, 424480, 424484, 424489, 424494, 424495, 424497, 424498, 424499, A61K 916, A61K 950, A61K 962, A61K 970
Patent
active
055409385
ABSTRACT:
Pharmaceutical formulations comprise a mono- or di-aminopyridine active agent for administration on a once- or twice-daily basis for use in the treatment of neurological diseases, in particular multiple sclerosis and Alzheimer's disease. The formulations, which are suitable for oral or percutaneous administration of the active agent, include the active agent in a carrier effective to permit release of the mono- or di-aminopyridine at a rate allowing controlled absorption thereof over, on the average, not less than a 12 hour period and at a rate sufficient to achieve therapeutically effective blood levels over a period of 12-24 hours following administration.
REFERENCES:
Davis et al., "D. of the Rush Multiple Sclerosis Center".
Bever et al., Ann. Neurol. 27(4), pp. 421-427 (Apr. 1990).
Wesseling et al., N. Eng. J. of Med., 310(15), pp. 988-989 (Apr. 1984).
Masterson Joseph G.
Myers Michael
Azpuru Carlos
Church Marla J.
Elan Corporation, plc
Page Thurman
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