Formulations and their use in the treatment of neurological dise

Details Formulations and their use in the treatment of neurological dise Formulations and their use in the treatment of neurological dise

1995-06-07

1996-12-03

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424445, 424449, 424451, 424452, 424458, 424460, 424462, 424464, 424465, 424474, 424475, 424480, 424484, 424489, 424494, 424495, 424497, 424498, 424499, A61K 916, A61K 950, A61K 962, A61K 970

Patent

active

055805809

ABSTRACT:
Pharmaceutical formulations comprise a mono- or di-aminopyridine active agent for administration on a once- or twice-daily basis for use in the treatment of neurological diseases, in particular multiple sclerosis and Alzheimer's disease. The formulations, which are suitable for oral or percutaneous administration of the active agent, include the active agent in a carrier effective to permit release of the mono- or di-aminopyridine at a rate allowing controlled absorption thereof over, on the average, not less than a 12 hour period and at a rate sufficient to achieve therapeutically effective blood levels over a period of 12-24 hours following administration.

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Davis et al, D. of the Rush Multiple Sclerosis Center.
Bever et al, Ann Neurol. 27(4), pp. 421-427 (Apr. 1990).
Wesseling et al, N. Eng. J. of Med, 310(15), pp. 988-989 (Apr. 1984).
"4-Amino Pyridine Tablets; A Method for the Preparation [and] in Vitro and in Vivostudies", Uges et al., Pharm. Acta Helu., 57(4) pp. 122-128, 1982, Abstract.
"4 Aminopyridine in the Treatment of Alzheimer's Disease", Davidson et al., Biol. Psychiatry 23(5), 1988 pp. 485-490.
"4 Aminopyridine Improves Clinical Signs in Multiple Sclerosis", Stefoski et al, Ann Neurol 21(1), 1987, pp. 71-77.
Barker, S. & Branford, D.; Pharm Journal Jan. 26, 1991, pp. 116-118.
Bever, C.T. Jr.: Leslie, J,; Camenga, D.L.; Panitch, H.S.; and Johnson, K.P., Ann. Neurol. 27(4), pp. 421-427 (Apr. 1990).

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