Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Patent
1997-04-18
1999-02-02
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
424649, 514431, 514517, 514707, A61K 4770
Patent
active
058666176
ABSTRACT:
This invention describes novel formulations containing a water soluble disulfide, 2,2'-dithio-bis-ethane sulfonate, with or without cis-diammine dichloro platinum present in the same formulation, wherein the parenteral or oral administration of 2,2'-dithio-bis-ethane sulfonate is used to reduce the risk or prevent or retard the development of cisplatin induced nephrotoxicity, myelosuppression, and neurotoxicity, and wherein the parenteral or oral administration of 2,2'-dithio-bis-ethane sulfonate potentiates the antitumor activity of cisplatin when treating human patients with cancer. This invention also teaches novel formulations containing 2,2'-dithio-bis-ethane sulfonate alone or in combination with cisplatin in lyophilized or dissolved in an aqueous formulations which can be administered to patients with cancer who are being treated with cisplatin. The invention also teaches methods of preparing said formulations and their use in preventing cisplatin related toxicities and potentiation of cisplatin antitumor activity.
REFERENCES:
Leeuwenkamp et al, Eur J. Cancer 27(10), 1991 pp. 1243-1247.
Haridas Kochat
Hausheer Frederick Herman
Murali Dhanabalan
Peddaiahgari Seetharamulu
Reddy Dasharatha Gauravaram
BioNumerik Pharmaceuticals, Inc.
Dodd Thomas J.
Raymond Richard L.
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