Formulations and method of the percutaneous administration of le

Details Formulations and method of the percutaneous administration of le Formulations and method of the percutaneous administration of le

1992-06-12

1995-08-29

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530313, 530328, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

054460255

ABSTRACT:
Compositions useful for the percutaneous administration of leuprolide comprise from about 1 to about 100 mg/ml of leuprolide in its free base form, a cutaneous membrane penetration enhancing component, and a pharmaceutically acceptable carrier. The cutaneous membrane transport enhancing component comprises from about 1 percent to about 15 percent urea, from 1 percent to about 5 percent menthol, from about 0.5 percent to about 5 percent methyl salicylate, and from about 0.5 percent to about 5 percent camphor, all percentages expressed in weight/volume based upon the total volume of the composition.

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